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samtools

13 known vulnerabilities.

samtools at a glance

Last 12 months
13
Critical · all time
0
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0 10 20 December 2025: 0 vulnerabilities Dec 2025 January 2026: 0 vulnerabilities February 2026: 0 vulnerabilities March 2026: 12 vulnerabilities Mar April 2026: 0 vulnerabilities May 2026: 0 vulnerabilities June 2026: 0 vulnerabilities Jun July 2026: 0 vulnerabilities August 2026: 0 vulnerabilities September 2026: 0 vulnerabilities Sep October 2026: 1 vulnerability November 2026: 0 vulnerabilities
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13 results · Feed

  • Medium 4.4

    HTSlib through 1.24 Heap Out-of-Bounds Write via Truncated .gzi Index Count

    HTSlib through 1.24 contains a heap out-of-bounds write and read vulnerability in bgzf_index_load_hfile() in bgzf.c that allows attackers to corrupt heap memory by supplying a crafted .gzi index entry count. A count of 0xFFFFFFFF truncates noffs to zero, caus…

  • Medium 6.9

    NULL pointer dereference in samtools cram-size

    SAMtools is a program for reading, manipulating and writing bioinformatics file formats. Starting in version 1.17, in the cram-size command, used to write information about how well CRAM files are compressed, a check to see if the `cram_decode_compression_hea…

  • Medium 6.9

    samtools mpileup has use-after-free leading to an invalid read

    SAMtools is a program for reading, manipulating and writing bioinformatics file formats. The `mpileup` command outputs DNA sequences that have been aligned against a known reference. On each output line it writes the reference position, optionally the referen…

  • High 7.1

    HTSlib CRAM decoder vulnerable to buffer overflow

    HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. When reading data encoded using the `BYTE_ARRAY_LEN` method, th…

  • High 7.1

    HTSlib BGZF index file reader has a heap buffer overflow

    HTSlib is a library for reading and writing bioinformatics file formats. GZI files are used to index block-compressed GZIP [BGZF] files. In the GZI loading function, `bgzf_index_load_hfile()`, it was possible to trigger an integer overflow, leading to an unde…

  • High 7.1

    HTSlib CRAM decoder has a heap buffer overflow

    HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. When reading data encoded using the `BYTE_ARRAY_STOP` method, a…

  • High 8.8

    HTSlib CRAM decoder vulnerable to buffer overflow

    HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. For the `VARINT` and `CONST` encodings, incomplete validation o…

  • Medium 6.9

    HTSlib CRAM reader has out-of-bounds read due to improper validation of input

    HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. In the `cram_decode_slice()` function called while reading CRAM records, the value of the mate reference id field wa…

  • Medium 6.9

    HTSlib CRAM reader has out-of-bounds read due to improper validation of input

    HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. As one method of removing redundant data, CRAM uses reference-based compression so that instead of storing the full …

  • Medium 6.9

    HTSlib CRAM reader has out-of-bounds reads due to improper validation of input

    HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. In the `cram_decode_slice()` function called while reading CRAM records, validation of the reference id field occurr…

  • Medium 6.9

    HTSlib CRAM decoder has a NULL Pointer Dereference

    HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. While most alignment records store DNA sequence and quality val…

  • High 8.8

    HTSlib CRAM reader has heap buffer overflow due to improper validation of input

    HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. As one method of removing redundant data, CRAM uses reference-based compression so that instead of storing the full …

  • High 8.8

    HTSlib CRAM reader has heap buffer overflow due to improper validation of input

    HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. While most alignment records store DNA sequence and quality values, the format also allows them to omit this data in…